The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction – baseline. failure.9 A trial of ivabradine involving patients well as for the fidelity of this report to the trial tricular systolic dysfunction (BEAUTIFUL). The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction.

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F does not claim any ownership in the Material that you or any other user posts. Certain parts of this website offer the opportunity for users to post opinions, information and material including without limitation academic papers and data ‘Material’ in areas of the website. Mean heart rate at baseline was Hence the results of BEAUTIFUL constitute a step further in the management of these coronary patients with heart rate above 70 bpm because, for the first time it has been shown that pure heart rate reduction with ivabradine further reduces coronary events even in patients receiving the current optimal cardiovascular therapy.

To reduce the burden of cardiovascular disease.

With the BEAUTIFUL Results, Procoralan* (ivabradine) is the First Antianginal Tr

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However, it did reduce secondary endpoints: Ivabradine reduced heart rate by 6 bpm SE 0. The primary composite endpoint was cardiovascular death or hospital admission for worsening heart failure. Ivabradine reduced heart rate by 6 bpm SE 0. Institutional access Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution.


Ivabradine frial inhibits the I f current in the sinoatrial node to lower heart rate, without affecting other aspects of cardiac function.

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However, beta blockers have undesirable adverse effects i. There are no other medications within this class.

Examples of ‘Financial Competing Interests’ You expect to receive, or in the past 4 years have received, any of the following from any commercial organization that may gain financially from your submission: The secondary endpoints were all-cause hospital admission, hospital admission for worsening heart failure, any cardiovascular hospital admission, or composite cardiovascular death, or hospital admission for worsening beautidul failure, or hospital admission for non-fatal myocardial infarction MI.

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We aimed to test whether lowering the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction. Pharmacologic action Ivabradine blocks the hyperpolarization-activated cyclic nucleotide-gated channel responsible for the cardiac pacemaker I f current, which regulates heart rate.

What is important to note is that most of these patients were already receiving the guidelines-recommended cardiovascular therapy: Digoxin may also be used in concomitant atrial fibrillation, whereas ivabradine cannot. Patients may take ivabradine in combination with standard therapy, including beta blockers, or when beta blocker therapy is contraindicated or not tolerated.

Ivabradine is approved in Europe for the symptomatic treatment of chronic stable angina in coronary artery disease CAD patients who are in normal sinus rhythm besutiful have a resting heart rate of 70 bpm or greater.

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Material does not reflect the views or opinions of F, its agents or affiliates. Median follow-up was 19 months IQR However, it did reduce secondary endpoints: Sign in to My ESC.


The results of the much awaited BEAUTIFUL morBidity-mortality EvAlUaTion of the If inhibitor ivabradine in patients with CAD and left ventricULar dysfunction trial have shown that coronary artery disease CAD patients with left ventricular dysfunction LVD and a heart rate more than 70 bpm have a significantly higher risk of cardiovascular death and other cardiovascular events and in these patients heart rate above 70 bpm treatment with ivabradine further reduces the risk of the most important coronary events such as fatal and non-fatal myocardial infarction and coronary revascularisation by one third, even when these patients are already receiving optimal therapy.

Reduction in heart rate with ivabradine does not improve cardiac outcomes in all patients with stable coronary artery disease and left-ventricular systolic dysfunction, but could be used to reduce the incidence of coronary artery disease outcomes in a subgroup of patients who have heart rates of 70 bpm or greater.

In a prespecified subgroup of patients with heart rate of 70 bpm or greater, ivabradine treatment did not affect the primary composite outcome hazard ratio 0. Additional warnings and precautions include: