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AKG C568B PDF

The AKG CB is a professional condenser shotgun microphone whose capsule combines high directivity and wide frequency range. It is a perfect tool for . The C B Professional Small Condenser Shotgun Microphone from AKG is a short shotgun microphone designed for camera mounting and handheld. Hi guys, I just got a sweet deal on a couple of AKG CB shotgun microphones for my soon-to-be-mine DVX. I’ve read some pretty good.

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AKG CB any good? Page 1 of 2 1 2 Last Jump to page: Results 1 to 10 of I’ve read some pretty good reviews on them on various sites, but I was wondering if any of you guys have tried them on shoots with the DVX? The only reviews I’ve been able to find have been centered around music and theatre use BTW – I’m going to be making my own boom-pole and I’ll make sure to post pictures when it’s done: Originally Posted by tlorenzo. Long live the Power Mac.

AKG C568B Professional small condenser shotgun microphone

Power Mac Dual 2. Thought I’d resurrect this post.

This mic is touted as a hypercardiod and a shotgun. The manufacturer states “Below Hz it functions as a hypercardioid microphone; above Hz, the acoustic interference tube increases its directivity for extremely accurate pickup of distant sound. Means pretty much the opposite. It means that indoors the reverb will sound colored and ugly.

It is precisely that coloration that you are trying to avoid by using a hyper instead of a shotgun. Most shotguns have more of a hyper pattern at the low end.

It’s an unfortunate flaw in the fundamental design of interference tube mics. One that Schoeps use to poke fun at until recently for some darn reason.

To put aig slightly different spin on a post above: The windsock is also known as a dead cat, etc.

AKG CB Professional small condenser shotgun microphone-Avacab

Rycote and others make a combo wind protector that xkg the furry with the “blimp” but it only covers the front part of the mic. I haven’t actually used it yet I use a Sennheiser blimp, with a K-tek shock mount and K-Tek pistol grip.

C586b sound makes for a crappy movie, no matter how pretty the pictures. Check out my IMDB page: Originally Posted by Oleg 2. Family Fest ScriptFest X: Links monetized by VigLink.

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BANGLA KOBITA OF JOY GOSWAMI PDF

Joy Goswami (Bengali: জয় গোস্বামী; born ) is an Indian poet. Goswami writes in Bengali He has received the Anita-Sunil Basu Award from the Bangla Academy, Govt of W.B. the prestigious Ananda Purashkar in for Ghumiyechho. Free Bengali novel PDF Download now Kobita Sangroho by Joy Goswami and Read online Kobita Sangroho by Joy Boi.

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Joy was born on November 10, in Kolkata. His family moved to RanaghatNadia West Bengal shortly after and he has lived there ever since.

Goswami was introduced to and encouraged with respect to poetry by his father, Madhu Goswami a well-known freedom fighter in the area.

Free Book Download Store: Kobita Sangroho by Joy Goswami

He lost his father at the age of six, after which the family was sustained by his mother, a teacher. She died in Goswami’s formal education stopped early, in grade eleven.

By this time he was already writing poetry. After a long period of babgla in little magazines and periodicals, his writing was finally published in the influential Desh Patrika.

This brought his immediate critical acclaim and so long after his first poetry collection was published, named Christmas o Sheeter Sonnetguchchho Sonets of Christmas and Winter. Have you slept, Pine leaf?

Some MP3 recordings of him reading his poetry, along with a photograph, can be goswamo at the South Asian Literary Recordings Project page. From Wikipedia, the free encyclopedia.

Joy Goswami, Selected Poems – Asymptote

This biography of a living person needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediatelyespecially if potentially libelous or harmful. July Learn how and when to remove this template message.

Retrieved 9 July Retrieved from ” https: Views Read Edit View history. In other projects Wikimedia Commons.

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AIRTRONICS VG6000 MANUAL PDF

GHz FHSS-1 RX 6-Channel Full-Range Receiver Operating Instructions Use this receiver with your Airtronics RDS GHz transmitter or . We appreciate your purchase of this new AIRTRONICS. VG or VG Radio System. These instructions are intended to acquaint you with the many unique. Airtronics/Sanwa VG Modes? Radios. All; Planes; Sailplanes; Helis; FPV; Multirotors; Cars; Boats. About Sanwa VG Here you can.

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Due to differences in the implementation of 2.

This receiver operates on the 2. Unlike ordinary crystal-based systems, your model can be used without frequency control.

Always before use, conduct a mamual test to ensure that the servos operate properly. Also, conduct a range test at the area of operation to ensure that the radio control system has complete control of the model at the farthest reaches of the operational area.

The response speed of the receiver can be affected if used where multiple 2. Also, if response seems slow during use, discontinue use as quickly as possible.

Airtronics VG Transmitter/Receiver/Switch Harness – RC Groups

This ensures that your radio control system does not get hit by interference. Once the frequencies have been cleared, or the saturation level has dropped, your radio control system should be able to bind without any problems.

Observe any applicable laws and regulations in place at your flying site when using the 2. Unlike frequency bands used with earlier radio control systems, reception with this 2. Also, wire mesh and similar barriers can adversely affect operation. Keep this mind to ensure the safety of your model. Receiver Precautions l l l l l l l The receiver antenna wires consists of two coaxial cables and two reception wires the thin tip at the end of the coaxial cables.

When you mount the receiver antenna wires, do not bend the reception wires. Reception performance decreases if the reception wires are bent. The receiver antenna wires are delicate, therefore, handle with care. Do not pull on the receiver antenna wires with force. Do not cut or extend the receiver antenna wires. The coaxial cables the thicker portion of the receiver antenna wires can be bent into gentle curves, however, do not bend the coaxial cables acutely, or repeatedly bend them, or the antenna cores can be damaged.

When installed in an electric-powered model, keep the receiver antenna wires as far away from the motor, battery, and electronic speed control ESC as possible. There is a danger of runaway operation if connectors shake loose during use. Make sure that the receiver, servo sand switch harness connectors are securely fitted. The receiver is susceptible to vibration and moisture.

Take appropriate measures to protect against vibration and moisture. The receiver should be wrapped in foam and the foam should be secured aitrronics the receiver to hold it in place.

The foam should not be secured too tightly or the vibration dampening quality of the foam will be reduced. Failure to take appropriate measures could result in damage to the receiver. When installing the receiver, the antenna reception wires the thin tip at the end of the coaxial cables should not come into contact with any carbon or metal components conductive components.

Aircraft fuselages and helicopter frames may contain conductive components. If mounting the receiver surrounded by conductive materials for example, a carbon fiber fuselagemount the receiver sirtronics that the antenna airtrnoics wires can be extended outside of the model.

Reception can be blocked if the antenna reception wires are shielded inside a carbon fiber fuselage. It is extremely important to install the receiver and route the receiver antenna wires correctly in your model. This will ensure that your model receives control signals no matter what its posture, attitude, or heading.

For more information, see page 3. It airtgonics be dangerous if you activate the components in reverse order as the servos may start up inadvertently. Before use, double-check that the transmitter and receiver batteries are sufficiently charged.

Doing so may cause loss of transmitter output, making it impossible to control your model. Before use, the transmitter antenna should be angled so that the antenna is as close to perpendicular to the ground as possible during use. This is the optimum angle for use. After use, airtronis prevent any chance of damaging the antenna, the antenna should be moved into the horizontal stowed position.

Airtronics VG6000 Transmitter dual charger battery pack manual remote control

DO NOT operate your model again until you are certain the problem has been corrected. Your model can cause serious damage or injury, so please use caution and courtesy at all times. If you have little to no experience operating models, we strongly recommend you seek the assistance of experienced modelers or your local hobby shop for guidance.

This operation is referred to as ‘binding’.

AIRTRONICS VG6000 Manuals

Once the binding process is complete, the setting is remembered even when the transmitter and receiver are turned OFF, therefore, this procedure usually only needs to be done once for each separate receiver you’re using. If binding the receiver to an Airtronics SDG 2. The Bind LED on the transmitter will illuminate solid blue. The Bind LED on the receiver will blink slowly. The Bind LED on the receiver will continue to blink slowly.

Use the tip of a pencil or a 1. When the binding procedure is successful, the Bind LED on the receiver will stay solid blue when both the transmitter and receiver are turned ON.

In this case, turn both the transmitter and receiver OFF, then repeat the binding procedure. In addition, the receiver should be wrapped in foam rubber to protect it from vibration. Failure to mount the receiver antenna wires as described can result in poor reception, or in some cases, complete loss of reception. We recommend that you bind the transmitter and receiver prior to mounting the receiver into your model. The receiver should be mounted securely in your model and the receiver antenna wires installed per the diagram below.

Under no circumstances should the antenna reception wires be mounted parallel to each other. Coaxial Cables Reception Wire If mounting inside a carbon fiber fuselage, the antenna reception wires must be run outside of the model as described in the notation below. Alternatively, cut two short pieces of plastic tube and slide one antenna reception wire into each piece of tube, then tape or glue the tube to your model.

The tubes will protect the antenna reception wires from damage. For example, the Fail Safe can be set so that the throttle servo returns to low, the elevator moves slightly up, and the ailerons move slightly right or left, to result in a shallow decent.

Programmable Fail Safe is available on channels 1 through 4 only. The Bind LED on the receiver should illuminate solid blue, indicating that the transmitter and receiver are paired, then move the transmitter control sticks to verify that the servos are operating. The servos should move to the positions that you set in step 3. This will ensure that the transmitter and receiver are communicating properly prior to flight.

This airtroonics the safety of your model, yourself, and the people around you. If using the receiver with an Airtronics SDG 2. The Bind LED will blink slowly during this time. The transmitter airtrinics now in Low Power Mode. The transmitter will stay in Low Power Mode for 3 minutes. After 3 airtronocs, the transmitter will revert to Normal mode. If there is a problem with servo movement, try moving to a different position while still maintaining the same distance from your model, then check servo movement again.

If there is still a problem, do not fly. Check to make sure that vf6000 receiver, servos, switch, and onboard battery connections are correct and secure. Check to ensure that the antenna wires are correctly mounted. Do not attempt to fly with the transmitter in Low Power Mode. You will be unable to control your model once it is a certain distance away from you.

Before you fly, make sure that the Bind LED is illuminated solid blue! Please contact Airtronics Customer Service. Airtronics is Distributed Exclusively in North America by: It’s a community-based project which helps to repair anything.

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KIMPA VITA PDF

Kimpa Vita also called Dona Beatriz continued the resistance against the Portuguese slave traders. Prophetess Kimpa Vita (Dona Beatriz) (circa – ). Kimpa Vita (circa July 2, ), whose baptized name was Dona Beatriz, founded a religious sect known as the Antonians. The goal of this movement was . Vita kimpa was born in in the village called songololo, in the town of Bakongo at the time when the country was the Kingdom of Kongo Dia Ntotela.

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The avatar of Doctor Wonder July 2nd, Headsman. This remarkable woman claimed to be a medium for the spirit of Saint Anthony of Padua, a popular saint in the Catholicized Kingdom of Kongoand attracted a mass movement in the midst of civil war and social breakdown in the proud Kongo state.

Executed Today is pleased to mark this occasion with an interview with Boston University Prof. Thornton, author of The Kongolese Saint Anthony: This is a very unfamiliar story to most, as you point out in The Kongolese Saint Anthony.

The fita war in Kongo was basically a dynastic affair, that is, a battle between branches of the royal family for control over the throne. Kongo had a very highly centralized political structure, the king and his council had a lot of power not only over who held high office, but also kimap got what income, because a lot of income derived from holding office.

So controlling the kingship and its related patronage was very important.

THE BLACK SAINT AND PROPHETESS OF KONGO: KIMPA VITA (DONNA BEATRIZ)

This story is very complicated, I try to lay it out as simply as possible in Chapter II of my book. By that I mean that they spread the faith to a completely independent country and not just by conquest.

Officially, it was a series of miracles that both Catholic priests and Kongo elites witnessed in that led Nzinga a Nkuwuthe kimla of Kongo to become a Christian and be baptized on May 3, my birthday is May 3, which I have taken to be a sort of sign that I should be studying Kongo. Afonso provided for the funding of the church, created schools for teaching literacy and Christian religion for the nobility, had children educated in Portugal and returned to the country, and working with his own educated people and Portuguese priests also figured out how to vota the two traditions into a religion that was acceptable in the country.

The kings who followed elaborated and extended what Afonso started, especially by creating a network of schools all over the country. The Church grew again in the late sixteenth century when a series of kings named Alvaro I and II, father and son, in particular went a lot farther than Afonso had in Europeanizing Kongo. They gave the nobles titles of nobility in European fashion Counts, Dukes and Marquisthe brought in relics from Europe bones of martyrs, for exampleestablished an embassy in Rome, renamed the capital city as Sao Salvador, and vitta on.

The Kongolese ambassador to Rome, Antonio Manuel, who died in and is honored in a wing in the church ivta Santa Maria Maggiore in Rome, left personal papers when he died now found gita the Vatican archives.

They show the sort of culture a bita educated entirely in Kongo could show, in addition to a fascinating array of Kongolese administrative documents — the only ones we have. He also studied Carmelite mysticism, and had correspondence from many different people all over Europe. He was clearly at home among elite Europeans and was regarded by those kima met him as a cultured individual in a period when extra-Europeans were not always seen that way.

The Jesuits established a college in Kongo in and it provided advanced education along European lines until it was close just about the time that Beatriz was active.

Kongo had a library, in fact, though no trace of it exists vjta more, found on the second floor of the Jesuit college. So in short, the answer is that the political elite of the country decided in the sixteenth century to make their country a Catholic one, and they took vigorous steps to make it happen. They put teachers out all through the country, visiting priests from Europe constantly met these teachers in the rural areas, they were usually literate and possessed a good deal of knowledge of European culture, some had even lived in Europe.

Kimpa Vita of Kongo – Africa Heritages

These schoolmasters were the soul of the church; they instructed the people using a catechism in their own language afterprepared them for the sacraments and led weekly prayers at places of worship, usually large wooden crosses erected at key points all around the country. It was never a religion of conquest, and for that reason, the Kongos managed to make it their own without feeling they were abandoning or being forced to give up something.

In the sixteenth and seventeenth centuries foreign visitors often commented on how proud the Kongos were, of their country, their language, their food and the like, thinking that they were the best people in the kmipa. I go to Angola quite a bit and have been to Mbanza Kongo twice.

Kimpa Vita: African Prophetess

You can feel and hear that pride even now. During the colonial period roughly to in that area the Portuguese tried very hard to replace indigenous languages with Portuguese and to erase African culture in a systematic way, especially after But the Kongos simply refused to be erased: Today in Angola, you see in so many places that Portuguese is the language of daily life — even street kids shout at each other in Portuguese in Luanda and the land east all the way to Malange.

But in Mbanza Kongo and elsewhere in the north, the language of daily life is Kikongo, the ancient language of the country.

Their pride has been a problem for Kongo, too. In a lot of them were massacred in Luanda, partially for political reasons that are very complicated, but also I think because other Angolans resent this pride. But enough on that. Anyway, the Kongolese were proud to be not just Christians but Catholics.

The Portuguese tried to invade Kongo from Angola several times, first inthen vit inand finally in Each time they were decisively defeated. On the other hand, the Kongos were also unable to invade Angola, as they were repelled there also, first in and again in when the famous Battle of Mbwila was fought on the border between the two domains of Angola and Kongo.

This led to great hostility between Kongo and Portugal and especially its governors of Angola. Portuguese were massacred in the wake of the invasion and after the Battle of Mbwila inand by the s they had been effectively forced to leave the country, trading their only with Africa servants called pombeiros who represented their interests.

Priests were an exception. King Garcia II famously kimpaa a letter in which he proudly stated that they obeyed the Pope, vicar of Christ on earth, even though the Portuguese, whom they hated, had introduced them to the religion. Indeed, the only thing that we see in the correspondence of Kongolese kings that they do say good about Portugal was that it introduced them to the religion. The idea of a Catholic Kongo was reinforced when Kongo made an alliance with the Dutch.

This took place in in ikmpa aftermath of the failed Portuguese invasion. Pedro IIthe king, sent a letter to the Dutch States General proposing an alliance in which the Dutch would send a fleet to attack Angola by sea, and Kongo would send an army by land. The first attempt to do this in failed, in part because the Portuguese went out of their way to conciliate Kongo, but the second attempt, insucceeded and for a limpa the Kongo-Dutch alliance joined by the formidable Queen Njinga kijpa Ndongo-Matamba who was also at war with Portugal nearly drove the Portuguese out of Angola.

The Dutch hoped to use this opportunity to also convert Kongo to the Calvinism of the Dutch Reformed Church and they even had special literature designed to convert Catholics who spoke Portuguese to Calvinism. But Garcia II would have none of it, and had the books burned it was the seventeenth century after alland forced the ministers to leave.

He wrote a letter to the Dutch Estates General protesting the attempt and in it he made the statement I summarized in the paragraph above.

Kimpa Vita of Kongo

Kongo tried to make contact with Dutch speaking Catholic countries in the vta of the third failed Portuguese invasion in She was the daughter of a noble Kongo family from the region right around Kibangu, a flat-topped mountain that lays some distance east of the capital of Kim;a Kongo on a clear day you can vira that mountain from Mbanza Kongo. She seems to have had spiritual gifts even as a youth, and had dreams of playing with angels and visions and the like.

Not surprisingly, she turned to religious pursuits, becoming a nganga Marindaa spiritual person whose role the Catholic missionaries did not like, but was widely accepted in the Kongo as legitimate.

She was probably too spiritual and independent to be married, since she had two failed marriages by the time she began her fita. Her movement combines both a religious kimppa and a national restoration.

Is it even right to separate the secular and the religious dimensions? I think Beatriz was trying to end war as much as anything else. This was at the height of the slave trade: The slave trade was one of the byproducts of war along with death and destructionand because slavery was lucrative, it helped to continue the wars in a vicious cycle. As Beatriz understood it, the solution was to end the civil war and restore the kingdom.

None of the pretenders to the throne seemed able to do that. She thought that he had sent Saint Anthony do to that, and he had come to earth and chose to be incarnate in her. Beatriz had followers from all ranks and walks of life. Pedro IV had kimpq burned, but his own wife Hipolyta became a devotee.

Pedro was intrigued by her message himself. A number of the top contenders also were either tempted or became her followers.

It was the politics of her movement that got her in trouble. Once Beatriz threw herself in with Pedro Constantinho she was doomed because the other contenders became her enemies.

It was Pedro IV who managed to capture her, and he had her burned as a heretic and witch. Before she went over to Pedro Constantinho, Pedro IV had been very interested in her mission and protected her.

So someone named Joao would be called Ndozau, and someone named Miguel would be Ndomigel. As far as I can tell people got both names from their parents when they were born, and they probably started using the zina dia santu even before baptism.

King Antonio I had Vita as an element in his name; some people use this as evidence she was descended from this king who was killed in the Battle of Mbwila in cita I think such a fact would have been noted at the time and I doubt it. Nowadays, people in Angola and DRC tend to look vitaa on the zina dia santuwhich they view wrongly, I believe as a remnant vjta the colonial past. Many Angolans believe that somehow the Portuguese organized all that Christian stuff in Kongo and the local people resisted or rejected it.

I think the reason for this is twofold: Was there simply a pent-up need for renegotiating the way the faith worked for Kongolese? If so, did it happen in some other way after she was executed? I think she was concerned that Christianity was too European, and one of the things she chided the missionaries about was that they did not represent any black saints. She had vitw revelation from God on her side, she died every Friday and spent each weekend in Heaven conferring with the Heavenly Father about the affairs of Kongo and so what she got there was pretty much undeniable.

From these sessions in Heaven she learned the stories about Jesus being born in Nsundi, baptized in Sao Salvador and Mary being a slave of a Kongo marquis. There was probably a lot more richness to these stories that our accounts tell us. Kongos were pretty sure, I think, that God was an African and their pride also gradually placed stories in Africa, so in this way Beatriz was confirming what people believed or wanted to believe.

After her death, we find a lot of art objects, particularly crucifixes, in which Jesus is shown as an African his features are African and is wearing a cloth with a specifically Kongo design. Cecile Froment has recently competed a wonderful Ph.

They had the educational resources to support this, so they felt they should. But even when Kongo got its own bishop inthe kings of Portugal managed to get control of appointment and put Portuguese in there.

This was the cause of endless conflicts between the kings and the bishops, particularly because of the hostility between Portugal and Kongo over Angola.

Finally, a compromise was worked out. Beatriz came into this struggle on the Kongo side. While not denying the Capuchins their place as vitw, she contended with them over the theological questions. She lost this round, mostly for political reasons and not theological ones. She occupies the ruined former capital. Had she remained unmolested, what trajectory might her movement have been on? Of course occupying the capital was vital.

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AAHE MANOHAR TARI PDF

Aahe Manohar Tari – Sunita Deshpande. 13 likes. Book. I recently read one Marathi book called as “Aahe Manohar Tari” by Sunita Deshpande. She is wife of famous Marathi author P. L. Deshpande. Largest Online Books and Magazines Circulating Library in Mumbai. Read from collection of English Books, English magazines, Marathi Books, Marathi.

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Enter your mobile number or email address below and we’ll send you a link to download the free Kindle App. Then you can start reading Kindle books on awhe smartphone, tablet, or computer – no Kindle device mznohar.

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Aahe Manohar Tari / आहे मनोहर तरी

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BA6124 DATASHEET PDF

BA datasheet, BA circuit, BA data sheet: ROHM – LED level meter driver, 5-point, VU scale,alldatasheet, datasheet, Datasheet search site for. BA Datasheet PDF Download – LED level meter driver/ 5-point/ VU scale, BA data sheet. Rohm BA datasheet, LED level meter driver/ 5-point/ VU scale (1-page), BA datasheet, BA pdf, BA datasheet pdf, BA pinouts.

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Forums New posts Search forums. Media New media New comments Search media. Articles Top Articles Search resources. Welcome to our site! Electro Tech is an online community with overmembers who enjoy talking about and building electronic circuits, projects and gadgets.

(PDF) BA Datasheet PDF Download – LED level meter driver/ 5-point/ VU scale

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Thread starter joecool85 Start date Jul 13, I came across this chip and it looks really interesting. But the datasheet isn’t very explanatory. For instance, pin 7 is labeled as “Amp Output”, but what does that mean?

I would guess that the amp output is to drive an analogue meter or similar. NTE is basically a beefier replacement for the older BA series Vu meter driver originally manufactured by Rohm.

NTE1561 5 LED VU Meter IC questions

I don’t think NTE makes anything. They simply buy old parts, put their own number on b6a124 and triple the price. Their parts are replacements for the real thing so they do noy have details on their datasheets. If the original part is still manufactured then buy it instead.

NTE 5 LED VU Meter IC questions | Electronics Forum (Circuits, Projects and Microcontrollers)

Thanks vtech, very good info. Honestly I’ll probably just end up using an LM like everyone else, but this one is pretty cool and has better operating temperature range.

You cannot buy the original old Japanese IC because it is obsolete and is not made anymore.

But NTE will datashheet you one at their high price. The spacing for an LM is always 3dB from one step to the next step. I thought all chips like that were made in China these days.

Texas Instruments of America recently bought National Semi. You must log in or register to reply here. Replacing a 4 pin leaded inductor with a 2 pin Started by gkmaia Yesterday at Potentiometer Questions Started by norbss Yesterday at Started by fastline Yesterday at 8: Just saying hello Started by MichaelaJoy Yesterday at 6: This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.

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HIDROLASAS ACIDAS PDF

La denominación fosfatasa ácida (EC ) comprende un conjunto de enzimas por su enorme in especificidad, ya que miden la actividad enzimática de las fosfatasas ácidas de los diferentes tejidos y no sólo de la fracción prostática. La manosafosfato (M6P) es un monosacárido derivado de la manosa que se caracteriza por La M6P actúa como señal para las proteínas precursoras de las hidrolasas ácidas que están destinadas para ser transportadas hasta los. Start studying HIDROLASAS. Learn vocabulary, terms, and HIDROLASAS ACIDAS EN DIGESTION MACROMOLECULAS. HIDROLASAS. GLICOSIDASAS.

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Relation of CA polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase FAAH with obesity and insulin resistance.

Fosfatasa ácida – Wikipedia, la enciclopedia libre

A de Luis, M. The aim of our study was to investigate the relationship of missense polymorphism cDNA C- A of FAAH gene on obesity anthropometric parameters, cardiovascular risk factors and adipocytokines. An indirect calorimetry, tetrapolar electrical bioimpedance, blood pressure, a serial assessment of nutritional intake with 3 days written food records and biochemical analysis lipid profile, adipocytokines, insulin, CRP and lipoprotein-a were performed. The statistical analysis was performed for the combined CA and AA as a group and wild type CC as second group.

One hundred and ninety four patients No differences were detected between groups in anthropometric parameters and dietary intakes. According to recent surveys, approximately two thirds of the population of Spain is overweight 1. The current view of adipose tissue is that of an active secretory organ, sending out and responding to signals that modulate appetite, insulin sensitivity, energy expenditure, inflammation and immunity 2. Herbal Cannabis sativa marijuana has been known to have many psychoactive effects in humans including robust increases in appetite and body weight 3.

Nevertheless, the mechanism underlying cannabinoid neurobiological effects have been recently revealed 4. The endogenous cannabinoid system mediates and it is positioned both functionally and anatomically 5 to be an important modulator of normal human brain behavior. The main inactivating enzyme of endogenous cannabinoid receptor ligands is fatty acid amide hydrolase FAAHwhich has been identified as the catabolic enzyme capable of inactivating most of the endocannabinoids 6.

The pharmacological effects of some endocannabinoids appear to be regulated by FAAH activity 7suggesting that FAAH has the role to be a modulating enzyme for human behavior. However, in a large study sample subjectsJensen et al 11 were unable to find association of this polymorphism with overweight or obesity.

Considering the evidence that endogenous cannabinoid system plays a role in metabolic aspects of body weight and feeding behavior 12we decided to investigate the association of this FAAH missense polymorphism with obesity and adipocytokines.

Manosa-6-fosfato

These patients were recruited in a Nutrition Clinic Unit and signed an informed consent. Local ethical committee approved the protocol. All patients with a 2 weeks weight-stabilization period before recruitment were enrolled. Weight, blood pressure, basal glucose, c-reactive protein CRPinsulin, insulin resistance HOMAtotal cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides blood and adipocytokines leptin, adiponectin, resistin, TNF alpha, and interleukin 6 levels were measured at basal time.

A tetrapolar bioimpedance, an indirect calorimetry and a prospective serial assessment of nutritional intake with 3 days written food records were realized. Genotype of FAAH gene polymorphism was studied. Hideolasas primers and probes were designed with the Beacon Designer 4. DNA was denaturated at 95 o C for 3 min; this was followed by 50 cycles of denaturation at 95 o C for 15 s, and annealing at The PCR were run in a 25 uL hidfolasas volume containing Hardy Weinberg equilibrium was assessed.

Plasma glucose levels were determined by using an automated glucose oxidase method Glucose analyser 2, Beckman Instruments, Fullerton, California.

Lipoprotein a was determined by immunonephelometry with the aid of a Beckman array analyzer Beckman Instruments, Calif. Serum total cholesterol and triglyceride concentrations were determined by enzymatic colorimetric assay Technicon Instruments, Ltd. LDL cholesterol was calculated using Friedewald formula.

Normal values of IL6 was 1.

For the measurement of resting energy expenditure, subjects were admitted to a metabolic ward. Body weight was measured to an accuracy of 0. Waist narrowest diameter between xiphoid process and iliac crest and hip widest diameter over greater trochanters circumferences to derive waist-to hip ratio WHR were measured, too. Tetrapolar body electrical bioimpedance was used to determine body composition with an accuracy of 5 g An electric current of 0.

Resistance and reactance were used to calculate total body water, fat and fat-free mass. Blood pressure was measured twice after a 10 minutes rest with a random zero mercury sphygmomanometer, and averaged. Patients received prospective serial assessment of nutritional intake with 3 days written food records. All enrolled subjects received instruction to record their daily dietary intake for three days including a weekend day.

Handling of the dietary data was by means of a personal computer equipped with personal software, incorporating use of food scales and models to enhance portion size accuracy.

Records were reviewed by a registered dietitian and analyzed with a computer-based data evaluation system. National composition food tables were used as reference The distribution of variables was analyzed with Kolmogorov-Smirnov test.

Non-parametric variables were analyzed with the U-Mann-Whitney test. A p-value under 0. Two hundred and seventy nine patients gave informed consent and were enrolled in the study. The mean age was All subjects were weight stable during the 2 weeks period preceding the study body weight change, 0.

Age was similar in both groups wild type: Table I shows the anthropometric variables. No differences were hidolasas between groups. Table II shows the classic cardiovascular risk factors. Triglycerides, glucose and HOMA values were higher in wild type group than mutant type group. Table III shows nutritional intake with 3 days hidrolawas food records.

No statistical differences were detected in caloric, carbohydrate, fat, and protein intakes. Aerobic exercise per week was similar in both groups. Table IV shows levels of adipocytokines. IL-6 levels were higher in wild type group than mutant type group.

No differences were detected between both groups in other serum adipocytokine levels. Since genetic influences hidrolasass thought to play a greater role in obesity, identification of obesity genes may be more easily detected in the former. Studies of the CA variant and obesity from various authors have yeldied conflicting results In our study, the percentage of AA genotype 3. The percentage of AC genotype In our design, we investigated the effect of FAAH genetic variation on weight, and also on metabolic parameters.

An association between this polymorphism and metabolic profile hidfolasas been described. Interestingly, Aberle et al 24 have shown that carriers of the A allele had a significantly greater decrease in the total cholesterol and triglycerides as compared to wild type when folloging a low fat diet. The lack of association between this polymorphism and anthropometric parameters has been described by other authors.

The results of our study agree with those of Jensen et al 11 or Papazoglou et al 25 and axidas with those of Sipe et al 9. It is noteworthy that when BMI was evaluated hidrolassas a continous variable in subjects, the median BMI was significantly higher in subjects with the AA genotype compared to the median BMI of the other subjects 9. The effects of the FAAH AA could result in the upregulation of natural reward behaviours such as consumption of sweets and palatable food associated with overweigth and obesity.

Under normal circumstances, brain endocanabinoid signalling may exert tonic control on the levels of certain neurotransmitters. However, the inconsistencies between association studies may reflect the complex interactions between multiple population-specific genetic and environmental factors. Perhaps, these different results could be explained by inclusion criteria of subjects in previous studies of the literature.

These previous studies would require composition analysis of the diet to determine whether dietary components could be responsible for the lipid profile modifications. In our study dietary intake did not show statistical differences between groups, in this way our datas have been controlled by dietary intake and previous discrepancies could be explain by this uncontrolled factor dietary intake.

Accumulating evidence indicates hidtolasas the endogenous cannabinoid system is an essential homeostatic regulator of energy balance and weight via central appetite-stimulating mechanisms as well as peripheral lipogenesis The anatomical convergence of CB1 receptors and FAAH enzyme activity capable of regulating endocannabinoid tone supports the notion that FAAH is acidaa for regulation of endocannabinoid levels that could influence craving and reward behaviors through the relevant neuronal circuitry.

Patients with this polymorphism have half the FAAH enzymatic activity and protein expression when compared with wild-type subjects This provide a link between the consequences of this polymorphism and the present epidemiological study indicating that the FAAH AA polymorphism may play a role in decrease or increase metabolic risk associated to obesity.

In our study, the elevation of inflammation markers IL-6 in patients with wild type genotype could be related with an altered postprandial response of fatty acids absorption no measured hidrilasas our design. Elevated free fatty acids increases the acummulation of triglycerides in the adipocyte, related with imbalance of lipoprotein lipase activity and overproduction of adipokines such as IL The lack of association of this proimflammatory state with fat mass or BMI could indicate the existence of acida unmeasured gene-gene or gene-environment interactions that may enhance metabolic abnormalities in obese patients.

In conclusion, the novel finding of this study is the association of the mutant type group AC and AA of FAAH with a better cardiovascular profile triglyceride, glucose, interleukine 6 and HOMA levels than wild type group. Further studies are needed to elucidate this complex relationship in an independent way of body mass index.

Med hidrolasss Barc ; Current Atherosclerosis Hidroasas ; 7: The effects of cannabinnoids on the brain. Cloning and molecular characterization of the rat CB2 cannabinoid receptor.

Biochim Biophys Acta ; Endocannabinoids in the central nervous system an overview. Prostaglandins Leukot Essent Fatty acids ; The fatty acid amide hydrolase FAAH 1.

Fosfatasa ácida

Prostaglandins Leukot Essent Fatty Acids ; Pharmacological activity of fatty acid amides is regulated, but not mediated, by hifrolasas acid amide hydrolase in vivo. Pharmacol Exp Ther ; A Missense mutation in human fatty acid amide hydroxylase associated with problem drug abuse.

Overweight and obesity associated with a missense polymorphism ain fatty acd amide hydrolase FAAH. Inte J of Obes ;

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