Formulation of parenteral preparations the formulation of parenteral preparations need careful planning,thorough knowledge of medicaments and adjuvants to. Introduction. Parenteral preparations are defined as solutions, suspensions, emulsions for injection or infusion, powders for injection or infusion. 2. Chapter 13 – Formulation of Parenteral Products. Objectives. This chapter provides an overview of the development of injectable (parenteral) drug products.

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I am a Pharmacist. Chemistry Masala Personal Blog. These adjuvants should be used only when it is absolutely necessary to use them. It should be stressed that excipients should not adversely affect the intended medicinal action of the drug products, nor at the concentration used to cause toxicity or undue parenterald irritation.

So, buffers are used to adjust and maintain pH in order to increase stability, solubility, absorption and activity of API. Sunday, November 20, Metal ions enhance the oxidation process ,hence these are to be turned off by chelating agents. These are contrast media having radioactive iodine, chromium, technetium, iron etc meant for evaluation of organ functions. Used to prevent degradation and denaturation of injectable protein formulations such as insulin.

Antioxidants can be classified as:. Antioxidants can be classified as: The aqueous vehicle used are ;- 1 water for injections.

You do not have the permission to view this presentation. Emulsifying agents are used in sterile emulsions.

Go to Application Have a question? F suspending ,emulsifying and wetting agents: The pH is formulafion of the critical aspects of parenteral preparations which should have a pH close to the physiological one.


To make the formulation isotonic. These are sub visible particles. When drug substances are not soluble, dissolution can be achieved by the use of co-solvents, surfactants, or a soluble pro-drug, or eventually the use of solubility enhancers such formupation cyclodextrins thanks to the formation of inclusion complex.

Phenytoin sodium injection contains phenytoin that is solubilized in the water miscible solvent at pH 12 and if it is added to large volume formuulation, then precipitation occurs.

Prepared by following methods: Therefore it is not used commonly. Mineral oils cannot be used as they are not absorbed by body tissues. The excess use of adjuvants in parenteral products should be avoided as some of these may interfere with the drug. To disperse a water insoluble drug as a colloidal dispersion For wetting powders For better syringe ability Prevent crystal growth in suspensions For solubilizing steroids and fat soluble vitamins. It prevents loss of API from adsorption on process equipment.

Pharmacology Notes Education Website. The wetting agents are used to reduce the interfacial tension between the solid particles and the liquid, so as to prevent the formulation of lumps. In thisparent drug is modified. Upload from Desktop Single File Upload. Roquette has developed a pyrogen-free range of products with high pharmaceutical standards and being biocompatible for the manufacture of parenteral preparations, All these pyrogenfree range of products are obtained from natural and renewable raw materials.

In order to decrease drug solubility for improving its stabilitywe can: Drug formulated into injectable suspensions because: Unstable drug substances will lead to the formation of new impurities jeopardizing the safety of use of the preparations. Pharma recruitment news Education Website. Parenteral Preparations, Challenges in Formulations. Alcohol causes pain and tissue damage at the site of injection.


Modified by preparing estersalt or some other derivative in order to: Sections of this page.

Raw Materials Used in Parenterals Formulation |authorSTREAM

Parnterals changes to Flash or non-Flash embed. Fixed vegetable oils are used Prolong drug release at site of administration can be achieved when converted to oily suspension. When these are used as vehicles,then formulations should not be diluted with water as precipitation may occur. Parenteral preparations are defined as solutions, suspensions, emulsions for injection or infusion, powders for injection or infusion, gels for injection and implants.

They are added to protect components of the dosage form, which are subject to chemical degradation by oxidation. Study material for Pharma students updated their status.

Parenteral Preparations, Challenges in Formulations

Antioxidants prevent or inhibit oxidation of drug. It is the ability of od solid material to exist in more than one form or crystal structure.

See more of Study material for Pharma students on Facebook. Keep up with our latest articles, news and events. Ethyl alcohol is used in the preparation of hydrocortisone injection.

Elham Blouet, Pharmacist with several years of experience in industrial pharma companies and health authorities agency.

Metal ions enhance the oxidation process ,hence these are to be turned off by chelating agents PowerPoint Presentation: